Peculiarities of the virus-host cell relationship in a calf kidney cell line persistently infected with measles virus.
Acta Virol
; 24(4): 253-64, 1980 Jun.
Article
em En
| MEDLINE
| ID: mdl-6106376
ABSTRACT
Persistent infection with measles virus established in a calf kidney cell line differed in some features from other measles virus carrier systems. After a variable life span, ranging from 50 to 1100 days, six of the chronically infected cell lines showed an evolution towards lytic infection. Only one of these lines, the K-2 cell line, exhibited marked morphological, growth and chromosomal alterations suggesting in vitro cellular transformation. The transformed K-2 cells released infectious measles virus with several modified biological parameters. Persistent infection was not due to the accumulation of thermosensitive mutants or defective particles. The role of the host-cell factor and of the selection of the virus population during its passage in RV cells are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Viral
/
Efeito Citopatogênico Viral
/
Vírus do Sarampo
Limite:
Animals
Idioma:
En
Revista:
Acta Virol
Ano de publicação:
1980
Tipo de documento:
Article