Protease susceptibility of human A influenza virus polypeptides.
Acta Virol
; 25(3): 138-43, 1981 May.
Article
em En
| MEDLINE
| ID: mdl-6115561
ABSTRACT
The proteolytic susceptibility of polypeptides of four antigenically distinct subtypes of influenza a virus strains of human origin was studied. The extent of degradation of polypeptide molecules of strains A/PR/8/34 (H0N1) (PR), A/FM/1/47 (H1N1), A/Singapore/1/57 (H2N2) and A/Hong Kong/8/68 (H3N2), assessed by densitometry of gels after sodium dodecylsulfate polyacrylamide gel electrophoresis was variable by treatment with trypsin. Also, sequential treatment of PR strain initially with phospholipase D followed by proteases of different specificities suggested differences in susceptibility of surface and internal polypeptide molecules. The significance of these results is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
/
Peptídeo Hidrolases
/
Peptídeos
/
Proteínas Virais
Limite:
Animals
Idioma:
En
Revista:
Acta Virol
Ano de publicação:
1981
Tipo de documento:
Article