Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius.
Am J Trop Med Hyg
; 30(5): 1106-12, 1981 Sep.
Article
em En
| MEDLINE
| ID: mdl-6116436
ABSTRACT
Experimental parameters of infection and intraspecific transmission of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, in Apodemus agrarius rodents were determined. Mice inoculated by the intramuscular route experienced viremia for about 1 week beginning on day 7. After 3 weeks, immunofluorescent and neutralizing antibodies were present and no mouse ever developed signs of acute illness. Virus was recovered from lung, kidney, salivary gland, and liver, and virus excretion in urine, saliva, and feces occurred from about day 10 through day 360 (urine) post-inoculation. Antigen, but not infectious virus, was persistent in lung tissue for as long as 1 year. Horizontal contact infection occurred among cage-mates regardless of sexual pairing up to 360 days after infection and no evidence for participation of ectoparasitic arthropods in such transmission was obtained.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Febre Hemorrágica com Síndrome Renal
/
Muridae
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Am J Trop Med Hyg
Ano de publicação:
1981
Tipo de documento:
Article
País de publicação:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA