Effects of taxol and nocodazole on insulin secretion from isolated rat islets of Langerhans.
Biosci Rep
; 2(10): 795-801, 1982 Oct.
Article
em En
| MEDLINE
| ID: mdl-6129005
ABSTRACT
Taxol, a promotor of microtubule polymerization, and nocodazole, which induces microtubule depolymerization, used at concentrations known to be specific for these effects in other cell types, were each shown to inhibit glucose-stimulated insulin secretion from isolated rat islets of Langerhans. These findings suggest that the dynamic regulation of microtubule polymerization-depolymerization in pancreatic B cells may be important for insulin secretion via the microtubule-microfilamentous system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzimidazóis
/
Ilhotas Pancreáticas
/
Alcaloides
/
Insulina
Limite:
Animals
Idioma:
En
Revista:
Biosci Rep
Ano de publicação:
1982
Tipo de documento:
Article