[Effect of talinolol on the activity of the mixed-function oxidases of rat liver]. / Untersuchungen über die Wirkung von Talinolol auf die Aktivität der mischfunktionellen Oxidasen der Rattenleber.

ABSTRACT

Experiments with male rats were performed to compare the in vitro and in vivo effects of talinolol with those of propranolol, alprenolol, practolol, proadifen (SKF 525-A) and barbital. Three in vitro model reactions (amino-phenazone N-demethylation, p-nitroanisol O-demethylation and aniline hydroxylation) as well as the hexobarbital lateral-position time served as parameters. The results obtained show that talinolol, like the other beta-receptor blockers, can inhibit polyfunctional oxidases. There were no indications of an inductive action.