[Effect of talinolol on the activity of the mixed-function oxidases of rat liver]. / Untersuchungen über die Wirkung von Talinolol auf die Aktivität der mischfunktionellen Oxidasen der Rattenleber.
Pharmazie
; 37(11): 786-90, 1982 Nov.
Article
em De
| MEDLINE
| ID: mdl-6131443
ABSTRACT
Experiments with male rats were performed to compare the in vitro and in vivo effects of talinolol with those of propranolol, alprenolol, practolol, proadifen (SKF 525-A) and barbital. Three in vitro model reactions (amino-phenazone N-demethylation, p-nitroanisol O-demethylation and aniline hydroxylation) as well as the hexobarbital lateral-position time served as parameters. The results obtained show that talinolol, like the other beta-receptor blockers, can inhibit polyfunctional oxidases. There were no indications of an inductive action.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
/
Propanolaminas
/
Antagonistas Adrenérgicos beta
/
Oxigenases de Função Mista
/
Fígado
Limite:
Animals
Idioma:
De
Revista:
Pharmazie
Assunto da revista:
FARMACIA
Ano de publicação:
1982
Tipo de documento:
Article