Phenothiazines and structurally related compounds as inhibitors of adenosylmethionine decarboxylase: effects on the purified enzyme.
Biochem Int
; 8(2): 245-55, 1984 Feb.
Article
em En
| MEDLINE
| ID: mdl-6148082
ABSTRACT
The effects of chlorpromazine, imipramine, thioridazine, chlorprothixene, amitriptyline, desipramine and triflupromazine on adenosylmethionine decarboxylase purified from rat liver have been studied. The compounds caused competitive inhibition of the enzyme at 10(-5) - 10(-3) M concentrations. For chlorprothixene and triflupromazine the inhibition was linear, while the other drugs showed increasing, nonlinear inhibition at higher concentrations. Apparent Ki's for the compounds were between 6.8 X 10(-5) M (for chlorprothixene) and 6.4 X 10(-4) M (for desipramine). Inhibition of 50% under optimal assay conditions was achieved between drug concentrations of 1.3 X 10(-4) M (thioridazine) and 1.3 X 10(-3) M (imipramine).
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenosilmetionina Descarboxilase
/
Antipsicóticos
/
Carboxiliases
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Biochem Int
Ano de publicação:
1984
Tipo de documento:
Article