[Complexes of nonionic triether analogs of oligonucleotides with polynucleotides]. / Kompleksy neionnykh triéfirnykh analogov oligonukleotidov s polinukleotidami.

ABSTRACT

Alkyl triester analogues of oligodeoxynucleotides were synthesized [Tp(CH3)]8T(Ac), [Tp(C2H5)]8T, [dGp(C2H5)]2G, [dAp(C2H5)]2A. Their binding to complementary polyribo-and polydeoxyribonucleotides was studied by UV-spectroscopy and gel-filtration. The DNA complexes of analogues were shown to be more thermostable than the RNA ones independent on the nucleic base nature and alkyl residue size of the analogue used. Mg-salt increased the thermostability of the oligonucleotide analogue--RNA complexes.