Substance P-containing nerve fibres in large peripheral blood vessels of the rat.
Cell Tissue Res
; 229(2): 411-22, 1983.
Article
em En
| MEDLINE
| ID: mdl-6189613
ABSTRACT
Substance P-immunoreactive nerve fibres were localized by the indirect immunohistochemical method in the adventitia and the adventitial-medial border of large peripheral arteries and veins of the rat. Arteries showed a richer substance P-containing innervation than veins. The superior mesenteric artery was densely innervated, whereas no substance P-containing fibres were found around the carotid artery. Substance P produced a vasoconstriction of the veins, but was basically without effect on arteries, although with the carotid artery a dose-dependent relaxation was observed. The absence of a correlation between the degree of innervation of the blood vessels and their responsiveness to exogenous substance P suggests that there nerves do not subserve a vasomotor function. The depletion of substance P immunoreactivity from nerves in arteries and veins by capsaicin suggest that substance P-containing vascular nerves are primarily sensory in nature.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Substância P
/
Músculo Liso Vascular
/
Fibras Nervosas
Limite:
Animals
Idioma:
En
Revista:
Cell Tissue Res
Ano de publicação:
1983
Tipo de documento:
Article