Relationship between pulmonary function tests and morphologic changes in the lung in bleomycin-treated patients.
Tumori
; 70(5): 439-44, 1984 Oct 31.
Article
em En
| MEDLINE
| ID: mdl-6209835
ABSTRACT
The transfer factor of the lung for carbon monoxide (TLCO) and the respiratory response to moderate exercise were determined in 16 patients with pulmonary metastasis pretreated with bleomycin who underwent pulmonary partial resection. The results of pulmonary function tests were related to histologic findings. No significant correlation was found between pulmonary morphologic changes and the TLCO this questions the usefulness of TLCO as a predictive method for detecting subclinical bleomycin pulmonary toxicity. No significant correlation was found between morphologic findings and cumulative dose of bleomycin this confirms the limit of a dose limitation strategy. In contrast, evaluation of pulmonary response to exercise seemed to improve the sensitivity of monitoring such patients for clinical evidence of latent pulmonary toxicity; however, it seems that critical morphologic changes must occur before pulmonary performance begins to deteriorate.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testes de Função Respiratória
/
Bleomicina
/
Pulmão
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Humans
Idioma:
En
Revista:
Tumori
Ano de publicação:
1984
Tipo de documento:
Article