Frequency of qh+ chromosomal variants in a) radioexposed, b) Down syndrome and c) control subjects.
Boll Soc Ital Biol Sper
; 59(8): 1070-5, 1983 Aug 30.
Article
em En
| MEDLINE
| ID: mdl-6226304
ABSTRACT
"Paranormal" variants of human chromosomes, devoid of phenotypical effects (since what appears to vary is heterochromatic, non-genic DNA) are known to be heritable. Some very large variants (especially the qh+ variants on chromosomes 1 and possibly 16 and Y) were reported to be associated with increased reproductive pathology (sterility, fetal wastage, chromosomal aberrations). These variants are currently assessed by the C-band techniques; very large C-bands correspond to morphological alterations (elongation or deformation) of the chromosome. A study of qh+ morphological variants of chromosomes 1, 9 and 16 in 40 professionally radioexposed subjects, in 40 Down-syndrome patients and in 40 controls is reported, indicating that the frequency of each variant is lowest among controls, intermediate among professionally radioexposed subjects and highest among Down-syndrome patients. These findings, if confirmed, suggest a possible use of the qh+ variants as heritable indicators of chromosomal damage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radiologia
/
Aberrações Cromossômicas
/
Síndrome de Down
Limite:
Humans
/
Male
Idioma:
En
Revista:
Boll Soc Ital Biol Sper
Ano de publicação:
1983
Tipo de documento:
Article