Simultaneous analysis of a new cardiotonic agent, MDL 17,043, and its major sulfoxide metabolite in plasma by high-performance liquid chromatography.
J Chromatogr
; 306: 249-56, 1984 Mar 09.
Article
em En
| MEDLINE
| ID: mdl-6232282
ABSTRACT
MDL 17,043 or 1,3-dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one, is a new cardiotonic agent being developed for the treatment of congestive heart failure. This communication describes a sensitive and selective analytical procedure for the simultaneous analysis of MDL 17,043 and its major oxidative metabolite in plasma. The method involves addition of internal standard and organic solvent extraction, followed by separation with high-performance liquid chromatography and detection by ultraviolet absorption. The assay has good precision and accuracy. Evidence for the positive identification of the sulfoxide metabolite is also presented.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cardiotônicos
/
Imidazóis
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Chromatogr
Ano de publicação:
1984
Tipo de documento:
Article