Tonsillar metastasis from carcinoma of the breast with ultrastructural and steroid receptor analyses.
Laryngoscope
; 90(3): 477-85, 1980 Mar.
Article
em En
| MEDLINE
| ID: mdl-6244468
ABSTRACT
PIP: A case report and an ultrastructual study are published together to elucidate an unusual site of metastasis for mammary carcinoma. A 33-year-old American Indian mother presented with a left tonsillar mass; 11 months before she had undergone a right simple mastectomy for an apparently localized carcinoma of the breast. Biopsy material from the tonsillar mass contained carcinoma, and an axillary mass was subsequently excised and noted to contain similar tumor. After oophorectomy, the patient experienced remission of her bone pain and reduction in liver size. 5 figures form the bulk of the ultrastructural study. Histologically the tumor from the original mastectomy represented a medullary variant of infiltrating ductal carcinoma of the breast; the specimen was characterized by sheets of large bizarre, pleomorphic cells with hyperchromatic, pleomorphic nuclei and frequent mitosis. Only slight glandular differentiation of scirrhous reaction was apparent. The tonsillar biopsy contained several nodules of metastatic carcinoma with minimal adenomatous differentiation, bisicular nuclei, and prominent nuclei. Ultrastructurally, both metastatic foci of tumor were similar and characterized as adenocarcinomas with well-developed endoplasmic reticulum, cytoplasmic vacuolization, osmophilic granules, intracellular canaliculi with microvilli, numerous desmosomes, large nuclei with marginated nuclear chromatin, and enlarged nuceoli. Mitotic figures were abundant.
Palavras-chave
Biology; Breast Cancer--complications; Cancer; Case Studies; Clinical Research; Diseases; Endocrine System; Estradiol; Estrogens; Examinations And Diagnoses; Hormone Receptors--analysis; Hormones; Laboratory Examinations And Diagnoses; Laboratory Procedures; Membrane Proteins; Neoplasms; Physiology; Progestational Hormones; Progesterone; Research Methodology; Studies
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Receptores de Estrogênio
/
Neoplasias Tonsilares
/
Carcinoma Intraductal não Infiltrante
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Laryngoscope
Assunto da revista:
OTORRINOLARINGOLOGIA
Ano de publicação:
1980
Tipo de documento:
Article