A comparison of 3,4-diaminopyridine and 4-aminopyridine in the anaesthetized cat.
Eur J Pharmacol
; 84(3-4): 215-9, 1982 Oct 22.
Article
em En
| MEDLINE
| ID: mdl-6293848
ABSTRACT
3,4-Diaminopyridine and 4-aminopyridine were compared in the anaesthetized cat and found to be equiactive in their anti-curare activity. This in vivo similarity is at variance with previous in vitro studies which demonstrate 3,4-diaminopyridine to be more active than 4-aminopyridine at the neuromuscular junction. Possible reasons for the similarity between the two aminopyridines at the in vivo neuromuscular junction are discussed and it is concluded that 3,4-diaminopyridine has only marginal advantages over 4-aminopyridine as a potential anti-curare agent.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aminopiridinas
/
Junção Neuromuscular
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1982
Tipo de documento:
Article