Synthesis and characterization of a novel inhibitor of an aminoglycoside-inactivating enzyme.
J Antibiot (Tokyo)
; 35(12): 1651-7, 1982 Dec.
Article
em En
| MEDLINE
| ID: mdl-6300011
ABSTRACT
A novel low-molecular weight inhibitor of an aminoglycoside-inactivating enzyme, initially isolated from fermentation broths of Streptomyces neyagawaensis, was determined to be 7-hydroxytropolone. Its structure was confirmed by synthesis. In vitro synergy was demonstrated between 7-hydroxytropolone and certain aminoglycosides against bacteria which were resistant to those aminoglycosides by virtue of a 2"-O-adenylyltransferase. The synthesis and characterization of some analogs of 7-hydroxytropolone is also described.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Tropolona
/
Cicloeptanos
/
Antibacterianos
/
Nucleotidiltransferases
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1982
Tipo de documento:
Article