Karyotype evolution in a transformed rat cerebral endothelial cell line.
Int J Cancer
; 32(4): 485-90, 1983 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-6311760
ABSTRACT
Primary cultures of rat microvascular endothelial cells were transformed, in vitro, by exposure to Rous sarcoma virus. Transformed cells were followed and evaluated cytogenetically through numerous passages. Highly specific karyotypic changes in karyotype (both structural and numerical) were documented. These changes became established and intimately involved in further "karyotypic evolution". The findings were reproducible, and when considered in the light of the literature suggest regular patterns of karyotypic change in rat tumors. The in vitro methodology utilized promises to be of practical value in the study of the early stages of malignancy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
Células-Tronco Neoplásicas
/
Infecções Tumorais por Vírus
/
Transformação Celular Viral
Limite:
Animals
Idioma:
En
Revista:
Int J Cancer
Ano de publicação:
1983
Tipo de documento:
Article