Pharmacokinetics of nabilone, a psychotropically active 9-ketocannabinoid, in the dog. Utilization of quantitative selected ion monitoring and deuterium labeling.
Biomed Mass Spectrom
; 5(4): 296-301, 1978 Apr.
Article
em En
| MEDLINE
| ID: mdl-638236
ABSTRACT
Quantitative selected ion monitoring methods for the determination of plasma concentrations of nabilone, a psychotropically active 9-ketocannabinoid, and two carbinol metabolites using deuterium labeled internal standards are described. These specific methods have a lower limit of sensitivity of about 2 pmol ml-1 with a coefficient of variation of less than 4%. The utility of these methods was demonstrated by in vivo studies of single dose and steady state pharmacokinetics of nabilone and its carbinol metabolites in the dog.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dronabinol
Limite:
Animals
Idioma:
En
Revista:
Biomed Mass Spectrom
Ano de publicação:
1978
Tipo de documento:
Article