On the seemingly diminished CO2-Bohr effect in hypoxic chemodenervated rabbits.
Adv Exp Med Biol
; 169: 163-73, 1984.
Article
em En
| MEDLINE
| ID: mdl-6428180
ABSTRACT
In hypoxic rabbits, different levels of Pco2 before and after carotid chemodenervation were applied in order to get information about the acid-base status and the position of the O2-Hb dissociation curve (ODC). A CO2-induced change in pH caused a smaller change in the half-saturation pressure (P50) than was to be expected from the CO2-Bohr effect alone. Considering both, the numerically different CO2- and fixed acid-Bohr factors as well as the corresponding respiratory or metabolic pH changes, a method is presented to calculate the position of the ODC with high accuracy. From these considerations it can be derived that the seemingly diminished CO2-Bohr effect in hypoxic rabbits in vivo, especially after chemodenervation , is due more or less to accumulation of lactid acid. This leads to an increasing error if only the CO2-Bohr factor and the actual pH change are taken into account.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
/
Dióxido de Carbono
/
Hipóxia
/
Músculos
Limite:
Animals
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
1984
Tipo de documento:
Article