Emergence of Streptococcus faecalis isolates with high-level resistance to multiple aminocyclitol aminoglycosides.
Diagn Microbiol Infect Dis
; 2(3): 171-7, 1984 Jun.
Article
em En
| MEDLINE
| ID: mdl-6430629
ABSTRACT
Isolates of Streptococcus faecalis were occasionally found to be resistant to gentamicin concentrations of 500 micrograms/ml in a microdilution tray. Additional tests were performed with 28 such isolates. They all demonstrated high-level resistance (minimum inhibitory concentration greater than 2000 micrograms/ml) to gentamicin, kanamycin, sisomicin, streptomycin, and tobramycin. This high-level aminoglycoside resistance was associated with total resistance to in vitro synergism when each aminoglycoside was combined with ampicillin. In addition to ampicillin-aminoglycoside combinations, ampicillin-vancomycin, ampicillin-rifampin, rifampin-vancomycin, and vancomycin-gentamicin combinations were also tested; all failed to exhibit an in vitro synergistic-bactericidal effect against these enterococci. The emergence of enterococci with high-level resistance to multiple aminoglycosides in this clinical population is a source of grave concern with obvious therapeutic implications in situations such as endocarditis, where an in vitro bactericidal effect is thought to be necessary for a cure. No drug or combination of drugs was found to be bactericidal for these isolates. It is suspected that similar isolates of group D streptococci with high-level resistance to gentamicin may emerge in other institutions but go unrecognized. Surveillance by others for identifying this newly emerging pathogen carrying multiple resistance and a continued search for a satisfactory chemotherapeutic agent(s) are encouraged.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Enterococcus faecalis
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
Diagn Microbiol Infect Dis
Ano de publicação:
1984
Tipo de documento:
Article