Tetracyclines inhibit parathyroid hormone-induced bone resorption in organ culture.
Experientia
; 40(11): 1273-5, 1984 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-6500016
ABSTRACT
Several tetracyclines (minocycline, doxycycline, tetracycline), in levels approximating physiologic concentrations, were found to inhibit parathyroid hormone-induced bone resorption in organ culture; the specificity of this effect was demonstrated by comparison with other (non-tetracycline) types of antibiotics. The ability of tetracyclines to inhibit bone resorption is consistent with the recent proposal by Golub et al. that these antibiotics can inhibit mammalian collagenolytic enzymes by a mechanism unrelated to the drug's antibacterial efficacy, a property which could be therapeutically useful in diseases characterized by excessive collagen breakdown.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio Paratireóideo
/
Tetraciclinas
/
Osso e Ossos
/
Reabsorção Óssea
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Experientia
Ano de publicação:
1984
Tipo de documento:
Article