[Proteases from the enterocytes of the porcine small intestine. Role of aminopeptidase N in the transport of dipeptides]. / Proteazy énterotsitov tonkogo kishechnika svin'i. Rol' aminopeptidazy N v transporte dipeptidov.
Biokhimiia
; 49(11): 1854-61, 1984 Nov.
Article
em Ru
| MEDLINE
| ID: mdl-6525363
ABSTRACT
The kinetics of radioactive label uptake from [U-14C]Gly, L-[4.5-3H]Leu and dipeptide [U-14C]Gly-L-[4.5-3H]Leu by the brush border membrane vesicles of porcine small intestine have been studied. The effect of aminopeptidase N inhibitors and of leucine-binding protein on the accumulation rates has been investigated. A comparison of the kinetic parameters for the uptake and hydrolysis of Gly-L-Leu, has demonstrated that the dipeptide transfer includes two conjugated steps, i. e., hydrolysis catalyzed by aminopeptidase N and transport of the resultant free amino acids by a specific carrier.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dipeptídeos
/
Aminopeptidases
/
Intestino Delgado
Limite:
Animals
Idioma:
Ru
Revista:
Biokhimiia
Ano de publicação:
1984
Tipo de documento:
Article