Normal modes of vibration of a model peptide adopting the C7 C5 structure. Application toi angiotensin II.

ABSTRACT

A normal coordinate treatment was performed on the C7C5 conformation using a modified Urey-Bradley force field refined from previous studies on beta-turns. The predicted frequencies were compared with the experimental ones obtained on the peptide hormone human angiotensin II. The existence of both a beta-turn and a C7C5 conformation in solid and in aqueous solution is discussed.