Gas-liquid chromatographic method for the routine estimation of disopyramide in plasma or serum.
J Chromatogr
; 152(2): 501-6, 1978 May 21.
Article
em En
| MEDLINE
| ID: mdl-659546
ABSTRACT
A rapid, sensitive and specific gas-liquid chromatographic method is presented for the routine monitoring of plasma concentrations of the anti-arrhythmic compound, disopyramide. The procedure involves extraction of the drug from alkaline plasma into ether, purification of the extract and gas chromatographic analysis using OV-101 liquid phase and flame ionization detection. The results demonstrate the accuracy and reproducibility of the method. Contrary to a previous report, it has been shown that delay in separating plasma from erythrocytes does not affect the disopyramide level in plasma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Disopiramida
Limite:
Humans
Idioma:
En
Revista:
J Chromatogr
Ano de publicação:
1978
Tipo de documento:
Article
País de publicação:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS