Histamine-releasing effect of a corticotrophin derivative. I. Histamine-releasing effect of a nonadecapeptide in comparison with that of other histamine liberators.
Pharmacology
; 15(2): 134-42, 1977.
Article
em En
| MEDLINE
| ID: mdl-66701
ABSTRACT
The histamine-liberating properties of a synthetic polypeptide (an a synthetic polypeptide (an alkylprolyl derivative of beta1-19-corticotrophin) were investigated under a variety of experimental conditions. It was found to be more potent in this respect than Compound 48/80, Melittin and Triton X-100. The degree of cell destruction observed in conjunction with the release of histamine induced by C 44 680-Ba suggests that the mode of action of the substance more closely resembles that of Compound 48/80 than that of Triton.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio Adrenocorticotrópico
/
Liberação de Histamina
Limite:
Animals
Idioma:
En
Revista:
Pharmacology
Ano de publicação:
1977
Tipo de documento:
Article