Sparteine oxidation by the human liver: absence of inhibition by mephenytoin.
Clin Pharmacol Ther
; 35(3): 426-8, 1984 Mar.
Article
em En
| MEDLINE
| ID: mdl-6697650
Recent population data suggest independence of the genetic polymorphisms in mephenytoin and sparteine/debrisoquine oxidation. We used human liver preparations to test whether mephenytoin competes with sparteine for binding to the genetically variable cytochrome P-450, which mediates metabolism of both sparteine and debrisoquine. Mephenytoin failed to inhibit in vitro sparteine oxidation. This provides biochemical evidence that the polymorphism of sparteine/debrisoquine metabolism is not related to that of mephenytoin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esparteína
/
Hidantoínas
/
Fígado
/
Mefenitoína
Limite:
Humans
Idioma:
En
Revista:
Clin Pharmacol Ther
Ano de publicação:
1984
Tipo de documento:
Article
País de publicação:
Estados Unidos