Effect of cytochalasin D on Toxoplasma gondii cell entry.
Infect Immun
; 20(3): 739-43, 1978 Jun.
Article
em En
| MEDLINE
| ID: mdl-669821
ABSTRACT
Cytochalasin D did not prevent attachment but did prevent entry of Toxoplasma gondii into peritoneal macrophages and bladder tumor 4934 cells. Inhibition of entry of T. gondii into peritoneal macrophages by cytochalasin D was dose related and comparable to inhibition of phagocytosis. Prevention of entry of T. gondii into bladder tumor 4934 cells by cytochalasin D followed a dose response identical to that observed with peritoneal macrophages. After removal of the medium containing cytochalasin D, its effect was completely reversible, and the kinetics of the loss of inhibition followed a similar time course for both phagocytic and "nonphagocytic" cell types. The studies support the concept that the host cells actively participate in the process by which T. gondii gains entry into cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fagocitose
/
Toxoplasma
/
Citocalasinas
/
Macrófagos
Limite:
Animals
Idioma:
En
Revista:
Infect Immun
Ano de publicação:
1978
Tipo de documento:
Article