Modified human fibrinogen labeled with 111In.

ABSTRACT

A method for the labeling of human fibrinogen with 111In is reported. The cyclic anhydride of DTPA, either dissolved in dimethyl sulfoxide or as the solid, is first covalently attached to the protein. The modified fibrinogen is then labeled with [111In]acetate, with an average yield of 90 +/- 3%. The product obtained is highly clottable and stable in vitro and has potential applications in imaging studies.