Experimental retinal detachment. VI. The permeability of the blood-retinal barrier.
Arch Ophthalmol
; 102(5): 747-51, 1984 May.
Article
em En
| MEDLINE
| ID: mdl-6721768
ABSTRACT
Fluorophotometry was used to study the permeability of the blood-retinal barrier in six monkeys with stable rhegmatogenous retinal detachments. Fluorescein transport was inhibited by probenecid. The rate of fluorescein disappearance (KvVv) was determined following intravitreal injection. In a separate experiment the equilibrium vitreous-plasma concentration ratio (Cv/Cp) was determined following intraperitoneal administration. Expressed in equivalent volumes of vitreous, the rate of fluorescein diffusion across the blood-retinal barrier (K'vVvCv/Cp) was 0.29 microL/min in control eyes and 0.73 microL/min in detached eyes. The rate of fluid movement across the blood-retinal barrier (K'vVv) [1 - (Cv/Cp)] was 2.89 microL/min in control eyes and 6.38 microL/min in detached eyes. Posterior movement of fluid contributes to retinal apposition under normal conditions and accounts for the rapid resolution of retinal detachment following closure of the retinal hole.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Descolamento Retiniano
/
Permeabilidade Capilar
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Arch Ophthalmol
Ano de publicação:
1984
Tipo de documento:
Article