Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.
J Cancer Res Clin Oncol
; 104(1-2): 115-31, 1982.
Article
em En
| MEDLINE
| ID: mdl-6813336
ABSTRACT
Colonic tumors were induced in male Sprague-Dawley rats by ten applications of 2 mg/kg/week N-nitrosoacetoxymethyl-methylamine (AMMN) or by three applications of 100 mg/kg/month 1,2-dimethylhydrazine (1,2-DMH). Application of AMMN and 1,2-DMH induced selective colonic tumors in 97% and 29-42% of the initial animals, respectively. Colonic-tumor-bearing animals were subjected to monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A. No cures were achieved. The different therapies did not exert any clear influence on the survival time of animals, except for animals pretreated with AMMN and then subjected to ftorafur therapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Fenilureia
/
Carcinógenos
/
Tegafur
/
Neoplasias do Colo
/
Dimetilidrazinas
/
Dimetilnitrosamina
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Fluoruracila
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Metilidrazinas
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Antineoplásicos
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Compostos de Nitrosoureia
Limite:
Animals
Idioma:
En
Revista:
J Cancer Res Clin Oncol
Ano de publicação:
1982
Tipo de documento:
Article