Kinetics of replication of lactate dehydrogenase-elevating virus in age-dependent polioencephalomyelitis.
Intervirology
; 19(1): 6-15, 1983.
Article
em En
| MEDLINE
| ID: mdl-6826331
ABSTRACT
The kinetics of replication of lactate dehydrogenase-elevating virus (LDV) in age-dependent polioencephalomyelitis was studied in genetically susceptible (C58/J) and resistant (C57BL/6J) mice. The peripheral replication pattern (plasma concentration) for LDV was similar in both strains. However, the concentration of virus within the central nervous system was strikingly different. In nonsusceptible C57BL/6J mice, little or no virus was found within the central nervous system. In the lumbar cord of susceptible C58/J mice, an increase in the concentration of LDV began 5 days postinfection and continued during the preclinical stages of disease. A direct correlation was shown between the concentration of LDV in spinal cord and the appearance of motor neuron disease but not the degree of inflammatory reaction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Replicação Viral
/
Encefalomielite
/
Vírus Elevador do Lactato Desidrogenase
/
Neurônios Motores
Limite:
Animals
Idioma:
En
Revista:
Intervirology
Ano de publicação:
1983
Tipo de documento:
Article