Effects of large doses of phenylbutazone administration to horses.
Am J Vet Res
; 44(5): 774-80, 1983 May.
Article
em En
| MEDLINE
| ID: mdl-6869982
ABSTRACT
The effects of large doses of phenylbutazone were evaluated in clinically normal horses. The drug was given to 4 groups of 2 horses each at the rate of 30 mg/kg of body weight, orally, or 30, 15, or 8 mg/kg IV daily for up to 2 weeks. All horses became anorectic and depressed after 2 to 4 phenylbutazone treatments, and the horses given 15 or 30 mg/kg died on or between days 4 and 7 of treatment. A decrease in total blood neutrophil count occurred in all horses, and was associated with toxic left shift in horses given the 2 larger dosage schedules. The horses also had progressive increases in serum urea nitrogen, creatinine, and phosphorus concentrations, accompanied by decreasing serum calcium concentrations. There was a progressive decrease in total serum protein in all 8 horses. Gastrointestinal ulcerations, renal papillary necrosis, and vascular thromboses were the predominant postmortem findings.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilbutazona
/
Gastroenteropatias
/
Doenças dos Cavalos
/
Nefropatias
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Vet Res
Ano de publicação:
1983
Tipo de documento:
Article