Non-linear kinetics of ethanol elimination in man: medico-legal applications of the terminal concentration-time data analysis.
Forensic Sci Int
; 21(3): 207-13, 1983.
Article
em En
| MEDLINE
| ID: mdl-6873778
ABSTRACT
Research regarding parameters suitable for reporting on the activity of enzymatic systems responsible for ethanol metabolism is of obvious interest in medico-legal practice. Blood ethanol concentration-time curves, following oral administration of ethanol, have been developed for ethylic and non-ethylic subjects. This study has confirmed the non-linear kinetics of ethanol elimination; however, existing non-linear models appear to be inadequate for usual medico-legal practice, because of their complexity. We observed three phases during the elimination of ethanol. The first order terminal phase is characterized by its half-life. This parameter seems adequate as a basis for determining the activity of enzyme systems responsible for the metabolism of ethanol.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Etanol
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Forensic Sci Int
Ano de publicação:
1983
Tipo de documento:
Article