Oral bioavailability and intravenous pharmacokinetics of amrinone in humans.
J Pharm Sci
; 72(7): 817-9, 1983 Jul.
Article
em En
| MEDLINE
| ID: mdl-6886991
ABSTRACT
Fourteen healthy males received two 75-mg doses of amrinone as a single capsule and as an intravenous solution in a single-dose crossover study. The mean (+/-SD) bioavailability, based on the area under the plasma concentration versus time curves, was 0.93 +/- 0.12. The plasma data for these subjects during the intravenous phase was described by an open two-compartment body model with a mean (+/-SD) apparent first-order terminal elimination rate constant, beta, of 0.19 +/- 0.06 hr-1, which corresponds to a half-life of 3.6 hr.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aminopiridinas
Limite:
Humans
/
Male
Idioma:
En
Revista:
J Pharm Sci
Ano de publicação:
1983
Tipo de documento:
Article