Experimental chronic epilepsy in rats: a screening method for antiepileptic drugs.
Pharmacol Res Commun
; 15(5): 553-8, 1983 May.
Article
em En
| MEDLINE
| ID: mdl-6889424
ABSTRACT
Rats were rendered epileptic by subpial injection of an FeCl3 solution. Epileptiform discharges, recorded by chronically implanted extradural electrodes, were evident within 48 h of surgery and persisted for more than 6 months. It is demonstrated that this model is useful for studying new antiepileptic agents since a series of clinically effective drugs (diazepam, clonazepam, Na phenobarbital, primidone, carbamezepine, ethosuximide, diphenylhydantoin, Na valproate, GABOB) show an activity which is does-dependent and within a range satisfactorily related to human dosages.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Anticonvulsivantes
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Animals
Idioma:
En
Revista:
Pharmacol Res Commun
Ano de publicação:
1983
Tipo de documento:
Article