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The effect of n-alkanols on the stationary current voltage behavior and action potential of myelinated nerve.
Biochim Biophys Acta ; 598(1): 200-5, 1980 May 08.
Article em En | MEDLINE | ID: mdl-6968222
Stationary current voltage characteristics and the action potential of single myelinated nerve fibres were measured to examine the effect of n-alkanols (methanol to octanol) on the electrophysiological function of the axon membrane. K+-depolarized membranes show alkanol-dependent shifts of VTr, the membrane transition voltage, whereas in veratridine-depolarized membranes such VTr-shifts are not observed. In the latter case, n-alkanols reduce both the stationary Na+ current and the conductivity step between the high- and low-ohmic conductivity state of the membrane. Action potential amplitude, however, is less affected by the alkanols as is the stationary Na+ current. The results are compared with the alkanol-dependent changes of the thermotropic phase transition in phospholipid bilayers.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Álcoois / Potenciais da Membrana / Fibras Nervosas Mielinizadas Limite: Animals Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 1980 Tipo de documento: Article País de publicação: Holanda
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Álcoois / Potenciais da Membrana / Fibras Nervosas Mielinizadas Limite: Animals Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 1980 Tipo de documento: Article País de publicação: Holanda