Hepatitis B virus surface antigen in glomerular immune complex deposits of patients with systemic lupus erythematosus.
Histopathology
; 6(2): 141-7, 1982 Mar.
Article
em En
| MEDLINE
| ID: mdl-7042512
ABSTRACT
In view of a high prevalence of hepatitis B virus infection in the Malaysian population, indirect immunofluorescence examination for hepatitis B surface antigen (HBsAg) was routinely performed on renal biopsy specimen at the University Hospital, Kuala Lumpur, over a 3-year period. Examination of renal tissue from 259 patients, including 47 with systemic lupus erythematosus (SLE), revealed 43 cases with HBsAg in glomerular immune complexes. A significantly high proportion (30/43) of these were SLE patients. The deposits were granular in nature, situated in both the capillary walls and mesangium and associated with immunoglobulin deposition. Morphological patterns of lupus nephritis involved were focal proliferative (one case), diffuse proliferative (23 cases) and membranous (six cases). None of these patients showed clinical evidence of liver disease. The significance of these findings remains uncertain, but the possibility exists that the hepatitis B virus may have a role in the pathogenesis of SLE in the tropics where both SLE and HBs antigenaemia are common.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Superfície da Hepatite B
/
Glomérulos Renais
/
Lúpus Eritematoso Sistêmico
/
Complexo Antígeno-Anticorpo
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Histopathology
Ano de publicação:
1982
Tipo de documento:
Article
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM