Demethylation of C14 2,3,4-trimethoxyphenylethylamine in schizophrenics before and after L-methionine loading.
Br J Psychiatry
; 140: 611-4, 1982 Jun.
Article
em En
| MEDLINE
| ID: mdl-7104550
ABSTRACT
Demethylation was compared in acute and chronic schizophrenics and in non-schizophrenics by the administration of C14 labelled 2,3,4-trimethoxyphenylethylamine (TMPEA). The results did not show a significant difference in the urinary levels of the monodemethylated catabolites of TMPEA among any groups of patients. However, there was a significant decrease in demethylation in untreated chronic schizophrenics after ten days of L-methionine orally, whereas the non-schizophrenic group similarly given methionine did not change. This suggests the possibility of a biological weakness in schizophrenia.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Mescalina
/
Metionina
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Br J Psychiatry
Ano de publicação:
1982
Tipo de documento:
Article