[Embryotoxic and teratogenic effect of Pharmachem tetramisole]. / Prouchvaniia za embriotoksichen i teratogenen efekt na tetramizol "Farmakhim".

ABSTRACT

Studies were carried out to establish the effect of high rates of Tetramizol Pharmachim on the embryonal and fetal development in rats. The preparation was administered orally to pregnant animals under the form of a 1 per cent solution at the rate of 1/5 LD50 (=200 mg/kg), on the fourth and the thirteenth day of gestation. It was found that the amount of the preparation applied on the fourth day after conception took place led to rise of the preimplantation loss of embryos. The rate of the total embryonal mortality also rose. Accordingly, it was concluded that in high doses Tetramizol Pharmachim could produce an embryotoxic effect on rats. The application of the preparation later during pregnacy (the 13th day) did not have an adverse effect on the normal course of gestation. No abnormal effects were demonstrated on the growth and development of fetuses during all stages of investigation, which might point to the teratogenic action of Tetramizol.