Synthesis and antibacterial and anticancer evaluations of alpha-methylene-gamma-butyrolactones.
J Pharm Sci
; 70(1): 84-6, 1981 Jan.
Article
em En
| MEDLINE
| ID: mdl-7229935
ABSTRACT
Nine new alpha-methylene-gamma-butyrolactones were synthesized by the Reformatsky condensation of ethyl alpha-bromomethylacrylate with ketones, aldehydes, and an epoxide. A unique spirobutyrolactone class was prepared by reaction of the zinc alkyl derivative and N-methylisatins. The compounds were evaluated against L-1210 and P-388 leukemia and the 9KB carcinoma of the nasopharynx. They also were screened in a microbiocidal and an antifungal assay. The spiro methylene lactone of 5-iodo-N-methylisatin displayed activity in the P-388, 9KB, and antifungal screens.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
4-Butirolactona
/
Furanos
/
Antibacterianos
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Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Pharm Sci
Ano de publicação:
1981
Tipo de documento:
Article