[Influence of the gastric acidity on the digoxinemia. Comparison between digoxin and beta-methyldigoxin (author's transl)]. / L'influenza dell'acidita' gastrica sulla digossinemia. Confronto fra diagnossina e beta-metildigossina.
G Ital Cardiol
; 10(12): 1669-74, 1980.
Article
em It
| MEDLINE
| ID: mdl-7250591
ABSTRACT
In a medium term study, carried out according to a random cross-over schema, the Authors have evaluated the influence of gastric acidity on the digoxinemia, after the administration of digoxin (0.375 mg/day) and beta-methyldigoxin (0.25 mg/day) from the same batches. The results confirmed the effect of the gastric acidity on cardiac glycosides and an higher stability of beta-methyldigoxin than digoxin. These data suggest that digoxin, particularly in patients with gastric hypoacidity, must be used cautiously, because we can reach decidedly dangerous haematic levels, with a mean deviation of the values from the normal subjects of 89%, in comparison with 18% in the beta-methyldigoxin treated patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Digoxina
/
Ácido Gástrico
/
Medigoxina
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
It
Revista:
G Ital Cardiol
Ano de publicação:
1980
Tipo de documento:
Article