Effects of ryanodine on the ionic currents and the calcium conductance in crab muscle fibers.
J Pharmacol Exp Ther
; 219(2): 526-33, 1981 Nov.
Article
em En
| MEDLINE
| ID: mdl-7288631
ABSTRACT
The effects of ryanodine, a neutral alkaloid, on crab muscle fibers were investigated under voltage clamp conditions using the double sucrose-gap technique. In the presence of ryanodine, contracture develops without any membrane depolarization and the Ca-conductance variables are shifted in a hyperpolarizing direction. As a result, the Ca channels are activated at the resting potential. During the action potential, the Ca channels appear to open faster and for a longer period of time. The K currents are also modified. These different effects may be interpreted by a common mechanism related to a change of the membrane electrical field induced by increased Ca activity in the cytoplasm.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rianodina
/
Cálcio
/
Braquiúros
/
Alcaloides
/
Músculos
Limite:
Animals
Idioma:
En
Revista:
J Pharmacol Exp Ther
Ano de publicação:
1981
Tipo de documento:
Article