[Experimental approach to the treatment of lupus nephritis by use of an accelerated model of the NZBxNZW mouse disease (author's transl)]. / Approche expérimentale du traitement des glomérulonéphrites lupiques à l'aide d'un modèle accéléré de la maladie des souris NZBxNZW.

ABSTRACT

An accelerated model of the NZBxNZW mouse disease is described. The acceleration of the disease was induced by the simultaneous injections of DNA complexed to methylated bovine serum albumin and of bacterial lipopolysaccharide which allow for the production, early in life, of high levels of anti-DNA antibodies. This new model was found to be suitable for therapeutic studies in mice with accelerated disease treated with cyclophosphamide and heparin.