Digoxin-quinidine interaction. Changes in canine tissue concentration from steady state with quinidine.
Am J Cardiol
; 45(6): 1196-200, 1980 Jun.
Article
em En
| MEDLINE
| ID: mdl-7377118
ABSTRACT
Tissue concentrations of tritiated digoxin inthe dog are altered by simultaneous administration of quinidine. Serum levels rise as tissue concentration decreases significantly in all tissue except brain tissue, where an increase of 51 percent is noted over that of the control digitalized state. The digitalis toxicity associated with digoxin-quinidine interaction appears to be associated with rising brain levels of digoxin and falling levels in the myocardium. These findings suggest a neurally mediated form of toxicity with this interaction related to a change in the space of distribution. The question of possible loss of inotropic effect associated with diminished myocardial digoxin concentration requires further study.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinidina
/
Digoxina
Limite:
Animals
Idioma:
En
Revista:
Am J Cardiol
Ano de publicação:
1980
Tipo de documento:
Article