Effect of ascorbic acid (vitamin C) on the epiphyseal plate of young guinea pigs receiving prednisolone.
Dev Pharmacol Ther
; 2(2): 69-79, 1981.
Article
em En
| MEDLINE
| ID: mdl-7472108
ABSTRACT
The effect of excess ascorbic acid on the epiphyseal plate of young guinea pigs receiving prednisolone over a period of 28 days has been investigated. The results show that the structural and morphologic changes caused in the epiphyseal plate of the animals receiving prednisolone are prevented by the simultaneous administration of excess ascorbic acid. These data are consistent with the hypothesis that pharmacological doses of ascorbic acid given concurrently to children receiving prolonged treatment with corticosteroids may prevent suppression of growth in these children.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
/
Prednisolona
/
Epífises
Limite:
Animals
Idioma:
En
Revista:
Dev Pharmacol Ther
Ano de publicação:
1981
Tipo de documento:
Article