Determination of clonazepam and its amino and acetamido metaoblites in human plasma by combined gas chromatography chemical ionization mass spectrometry and selected ion monitoring.
Biomed Mass Spectrom
; 5(12): 692-8, 1978 Dec.
Article
em En
| MEDLINE
| ID: mdl-747743
ABSTRACT
Our previously published gas chromatography chemical ionization mass spectrometry stable isotope dilution assay for clonazepam and its 7-amino metabolite in plasma has been modified to obtain more consistent recoveries of the amine metabolite and to permit the determination of the 7-acetamido metabolite of clonazepam. In addition, the manuscript describes the details of a method for a least squares analysis of the nonlinear standard curves associated with the use of certain stable isotope labeled analogs as internal standard.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espectrometria de Massas
/
Benzodiazepinonas
/
Clonazepam
Limite:
Humans
Idioma:
En
Revista:
Biomed Mass Spectrom
Ano de publicação:
1978
Tipo de documento:
Article