Reductions in tissue plasminogen activator and thrombomodulin in blood draining veins damaged by venous access devices.
Thromb Res
; 79(4): 369-76, 1995 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-7482440
A frequent complication of venous access devices (VADs) is axillary-subclavian venous thrombosis. To study this problem we have compared blood drawn through VADs with peripheral blood samples in a group of oncology patients with venographically demonstrated venous damage (N = 14) and a group with normal venograms (N = 21). The samples were assayed for a battery of proteins believed to be involved in thrombogenesis. After approximately six weeks of catheterization the venographically abnormal patients had significantly less thrombomodulin (P = 0.0055) and significantly higher PAI:tPA (P = 0.022) in catheter-drawn samples as compared with the venographically normal group. Although the data are inconclusive, it is hypothesized that these changes resulted from local endothelial injury.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cateteres de Demora
/
Ativador de Plasminogênio Tecidual
/
Trombomodulina
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Thromb Res
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos