Changes in liver drug glucuronidation during cholestasis are non predictable.
Arch Int Physiol Biochim Biophys
; 102(2): 121-3, 1994.
Article
em En
| MEDLINE
| ID: mdl-7519458
ABSTRACT
Liver microsomal glucuronidation of acetaminophen, chloramphenicol, salicylic acid, lorazepam, p-nitrophenol and morphine were measured in 8 days bile duct ligated rats. Compared to normals, cholestatic rats showed a decrease of 31% for p-nitrophenol glucuronidation; salicylic acid glucuronidation increased 281%; acetaminophen glucuronidation increased 38% while morphine, chloramphenicol and lorazepam values were similar to controls. We concluded that cholestasis produces non predictable changes on liver drug glucuronidation pathways.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Microssomos Hepáticos
/
Preparações Farmacêuticas
/
Colestase
/
Glucuronatos
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Arch Int Physiol Biochim Biophys
Assunto da revista:
BIOFISICA
/
BIOQUIMICA
/
FISIOLOGIA
Ano de publicação:
1994
Tipo de documento:
Article