Co-expression of endothelial cell and macrophage antigens in Kaposi's sarcoma cells.
J Pathol
; 173(1): 23-31, 1994 May.
Article
em En
| MEDLINE
| ID: mdl-7523640
ABSTRACT
The histopathogenesis of Kaposi's sarcoma (KS) was investigated using immunocytochemistry in 12 skin biopsies obtained from two AIDS patients, nine patients with the classic form, and one organ-transplant patient. KS cells revealed a peculiar antigenic profile, being characterized by co-expression of endothelial and macrophage markers. KS cells were stained for von Willebrand factor (vWF); for vascular endothelial (VE) cadherin, an endothelial specific adhesion molecule; and for PECAM/CD31. In addition, they expressed the macrophage antigens PAM-1, CD68, and CD14, and were positive for vitronectin receptor and alpha-1,5,6/beta-1 integrins. KS cells were weakly stained for ICAM-1 in 6 of 12 cases and were negative for VCAM-1 and E-selectin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma de Kaposi
/
Pele
/
Endotélio Linfático
/
Endotélio Vascular
/
Síndrome da Imunodeficiência Adquirida
/
Macrófagos
Limite:
Humans
Idioma:
En
Revista:
J Pathol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Itália