RNA expression of complement regulatory proteins in human brain tumors.
Cancer Lett
; 86(2): 143-9, 1994 Nov 11.
Article
em En
| MEDLINE
| ID: mdl-7526972
ABSTRACT
The expression of complement regulatory proteins (CRP) on the surface of neoplastic cells has been proposed as a mechanism by which these cells evade immune surveillance. We have examined the RNA expression of the genes that encode 5 kinds of CRP in various human brain tumors to determine whether CRP expression might play a role in the malignant progression of these tumors. The benign and atypical meningiomas, and the astrocytomas showed high expression of SP-40,40, low expression of CD59, and barely detectable expression of CD46, CD55 and S-protein. The benign and atypical menigiomas showed significantly greater expression of SP-40,40 at the RNA level when compared to malignant meningiomas. This study describes the mRNA expression of meningiomas, astrocytomas, tumor cell lines and normal human tissues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Proteínas Inativadoras do Complemento
/
RNA
/
Chaperonas Moleculares
Limite:
Humans
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1994
Tipo de documento:
Article