A decrease in neural sialyltransferase activity in Alzheimer's disease.
Dementia
; 6(4): 185-90, 1995.
Article
em En
| MEDLINE
| ID: mdl-7550596
ABSTRACT
The activities of both a particulate and soluble form of the sialyltransferase enzyme have been examined in post-mortem brain samples from Alzheimer's disease patients and age-matched controls. There was a considerable decrease in the activity of both the soluble and membrane-bound forms of the enzyme in the frontal and temporal cortical lobes, although no change was observed in the hippocampus. There was, however, no change in activity of the Golgi marker enzyme thiamine pyrophosphatase. Therefore, it is suggested that the decrease in sialyltransferase enzyme activity may be a specific biochemical event associated with the AD-like neurodegeneration.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sialiltransferases
/
Encéfalo
/
Doença de Alzheimer
Limite:
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
Dementia
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Reino Unido