Neural cell adhesion molecule (N-CAM) distribution may predict the effect of neurotoxins on the brain.
Toxicon
; 33(4): 577-81, 1995 Apr.
Article
em En
| MEDLINE
| ID: mdl-7570643
ABSTRACT
The neural cell adhesion molecule (N-CAM) is a convenient neurospecific marker for investigating the effects of neurotoxins on cell migration, cell recognition and differentiation of neurons during development. In this report, we discuss the developmental toxicity of valproic acid studied by two different approaches (the immunochemical detection of N-CAM content and polypeptide composition, and immunohistochemical analysis of N-CAM topography). Immunohistochemical analysis of distribution of N-CAM as a surface marker on the neural cells predicted the effect of the neurotoxin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Química Encefálica
/
Moléculas de Adesão de Célula Nervosa
/
Neurotoxinas
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Toxicon
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Ucrânia